Hydrochloric Acid → HCID 18445312, compound

Participants

Reaction Steps

Combine 4-(5-carbamoyl-pyridin-2-yloxy)-piperidine-1-carboxylic acid tert-butyl ester (1559 mg, 4.85 mmol) in tetrahydrofuran (25 mL) with hydrochloric acid (4.0 M in dioxane, 15 mL). Stir the resulting reaction mixture for 48 h. Filter the white precipitate washing with EtOAc (10 mL). Redissolve the white solid in methanol and concentrate to provide the title compound (1195 mg, 89%).

Provenance & Evidence