Hydrochloric Acid → HCID 18445312, compound

HRID 459922Notes

Reaction equation

HRID 459922 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21](=[O:23])[NH2:22])=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>O1CCCC1>[ClH:24].[NH:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([NH2:22])=[O:23])=[CH:17][N:16]=2)[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58794441HCID 58794441, compound

Product 1

HCID 18445312HCID 18445312, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Combine 4-(5-carbamoyl-pyridin-2-yloxy)-piperidine-1-carboxylic acid tert-butyl ester (1559 mg, 4.85 mmol) in tetrahydrofuran (25 mL) with hydrochloric acid (4.0 M in dioxane, 15 mL). Stir the resulting reaction mixture for 48 h. Filter the white precipitate washing with EtOAc (10 mL). Redissolve the white solid in methanol and concentrate to provide the title compound (1195 mg, 89%).

Workup

  1. customthe resulting reaction mixture for 48 h
  2. filtrationFilter the white precipitate
  3. washwashing with EtOAc (10 mL)
  4. dissolutionRedissolve the white solid in methanol
  5. concentrationconcentrate

Sources & evidence

ORD record
ord-889093af302442f1ad7809225ae6438d
Source dataset
uspto-grants-2007_03
Patent number
US07196100B2

Reaction notes

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