HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-[(Piperidin-4-yl)oxy]benzamide--hydrogen chloride (1/1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl 4-(4-carbamoylphenoxy)piperidine-1-carboxylate | HCID 23068080 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-[(Piperidin-4-yl)oxy]benzamide--hydrogen chloride (1/1) | HCID 18445305 | 99% |
Reaction Steps
Add hydrochloric acid (4M in dioxane, 3 mL) dropwise to a solution of 4-(4-carbamoyl-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester (228 mg, 0.711 mmol) in THF (2 mL). Stir at room temperature for 7 hours (h). Filter the solids and dry under reduced pressure to give the title compound (180 mg, 99%) as hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07196100B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-f4903cb15ebb404f84a2660cfa60df24 |
| Source note | uspto-grants-2007_03 |