Hydrochloric Acid → 4-[(Piperidin-4-yl)oxy]benzamide--hydrogen chloride (1/1)

HRID 459929Notes

Reaction equation

HRID 459929 reaction equation
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH:12]([O:15][C:16]2[CH:21]=[CH:20][C:19]([C:22](=[O:24])[NH2:23])=[CH:18][CH:17]=2)[CH2:11][CH2:10]1)=O)(C)(C)C>C1COCC1>[ClH:1].[NH:9]1[CH2:10][CH2:11][CH:12]([O:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]([NH2:23])=[O:24])=[CH:18][CH:17]=2)[CH2:13][CH2:14]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23068080tert-Butyl 4-(4-carbamoylphenoxy)piperidine-1-carboxylate

Product 1

HCID 184453054-[(Piperidin-4-yl)oxy]benzamide--hydrogen chloride (1/1)Yield 99%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Add hydrochloric acid (4M in dioxane, 3 mL) dropwise to a solution of 4-(4-carbamoyl-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester (228 mg, 0.711 mmol) in THF (2 mL). Stir at room temperature for 7 hours (h). Filter the solids and dry under reduced pressure to give the title compound (180 mg, 99%) as hydrochloride.

Workup

  1. filtrationFilter the solids
  2. customdry under reduced pressure

Sources & evidence

ORD record
ord-f4903cb15ebb404f84a2660cfa60df24
Source dataset
uspto-grants-2007_03
Patent number
US07196100B2

Reaction notes

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