Formaldehyde → HCID 131726312, compound

HRID 459937Notes

Reaction equation

HRID 459937 reaction equation
[ClH:1].[F:2][C:3]([F:36])([F:35])[C:4]1[CH:5]=[C:6]([C@H:14]([N:16]([CH3:34])[C:17]([N:19]2[C@@H:25]([C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:27]=3[CH3:33])[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[O:18])[CH3:15])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1.[CH2:37]=O>CO.[Pd]>[ClH:1].[F:36][C:3]([F:2])([F:35])[C:4]1[CH:5]=[C:6]([C@H:14]([N:16]([CH3:34])[C:17]([N:19]2[C@@H:25]([C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:27]=3[CH3:33])[CH2:24][CH2:23][N:22]([CH3:37])[CH2:21][CH2:20]2)=[O:18])[CH3:15])[CH:7]=[C:8]([C:10]([F:11])([F:12])[F:13])[CH:9]=1

Participants

5

Reactant 2

HCID 712FormaldehydeHCID 131726313HCID 131726313, compound

Product 1

HCID 131726312HCID 131726312, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of example 4 (10 mg), aqueous formaldehyde (29 μL) and 10% Pd/C (5 mg) in anhydrous MeOH (1 mL) was hydrogenated at r.t. and Patm. for 1 hour. The mixture was filtered and the organic layer was concentrated in vacuo. The residue was triturated with Et2O/pentane to give the title compound (5 mg) as a whitish solid.

Workup

  1. customwas hydrogenated at r.t.
  2. filtrationThe mixture was filtered
  3. concentrationthe organic layer was concentrated in vacuo
  4. customThe residue was triturated with Et2O/pentane

Sources & evidence

ORD record
ord-a3a225fe129348adb95b036bab6b484d
Source dataset
uspto-grants-2007_03
Patent number
US07196077B2

Reaction notes

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