反应详情

温度

0 °C

A solution of 7.19 g (assume 15.86 mmol) of (5-[(2,6-difluoro-3,5-dimethoxy-phenylimino)-methyl]-2-methylsulfanyl-pyrimidin-4-yl)-ethyl-amine in 130 mL of anhydrous tetrahydrofuran was cooled to 0° C. using an ice/acetone bath. The cooled mixture was treated dropwise via syringe with 23.79 mL (23.79 mol) of 1 M solution of lithium aluminum hydride in tetrahydrofuran which resulted initially with vigorous bubbling. The resulting mixture continued to stir at 0° C. for 1 hour under nitrogen atmosphere. The ice bath was removed and the reaction mixture was allowed to warm up to room temperature and continued stirring at room temperature overnight. The reaction mixture was cooled to 0° C. using an ice/acetone bath and quenched by the slow addition of 23.79 mL of water, 23.79 mL of 15% sodium hydroxide and 47.58 mL of water. The salts were filtered over a bed of Celite and removed the tetrahydrofuran in vacuo. The residue was redissolved in dichloromethane and filtered again. The layers were separated and dried the organic layer over sodium sulfate, filtered and evaporated. The crude product was purified using medium-pressure chromatography eluting with 2:1 hexanes/ethyl acetate to give 4.45 g (76%) of the title compound: mp 95° C.–99° C. MS (APCI) (m+1)/z 371.1.

1. customresulted initially with vigorous bubbling
2. customThe ice bath was removed
3. temperatureto warm up to room temperature
4. stirringcontinued stirring at room temperature overnight
5. temperatureThe reaction mixture was cooled to 0° C.
6. customquenched by the slow addition of 23.79 mL of water, 23.79 mL of 15% sodium hydroxide and 47.58 mL of water
7. filtrationThe salts were filtered over a bed of Celite
8. customremoved the tetrahydrofuran in vacuo
9. dissolutionThe residue was redissolved in dichloromethane
10. filtrationfiltered again
11. customThe layers were separated
12. dry with materialdried the organic layer over sodium sulfate
13. filtrationfiltered
14. customevaporated
15. customThe crude product was purified
16. washeluting with 2:1 hexanes/ethyl acetate