1,4-Dioxane hydrochloride → HCID 57453429, compound

HRID 45998Notes

Reaction equation

HRID 45998 reaction equation
[CH:1]1([N:4]2[CH2:9][CH2:8][N:7]([C:10]3([CH2:23][NH:24][C:25](=[O:32])[C:26]4[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=4)[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]3)[CH2:6][CH2:5]2)[CH2:3][CH2:2]1.[ClH:33].O1CCOCC1>O1CCOCC1>[ClH:33].[ClH:33].[CH:1]1([N:4]2[CH2:9][CH2:8][N:7]([C:10]3([CH2:23][NH:24][C:25](=[O:32])[C:26]4[CH:27]=[CH:28][N:29]=[CH:30][CH:31]=4)[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]3)[CH2:6][CH2:5]2)[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 57989611HCID 57989611, compound

Product 1

HCID 57453429HCID 57453429, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a cooled (0° C.) solution of tert-butyl 4-(4-cyclopropylpiperazin-1-yl)-4-(isonicotinamidomethyl)piperidine-1-carboxylate (0.541 mmol) in dioxane (1 ml/mmol) was added saturated dioxane-HCl solution (3.3 ml) and the reaction mixture was stirred at room temperature for 3 h. The solvent was evaporated and the residue was azeotroped with dioxane (3×). The crude product was used in the next step.

Workup

  1. customThe solvent was evaporated
  2. customthe residue was azeotroped with dioxane (3×)

Sources & evidence

ORD record
ord-d65242979f6b41dfb9a31a13db736381
Source dataset
uspto-grants-2013_09
Patent number
US08541573B2

Reaction notes

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