1,4-Dioxane hydrochloride → HCID 57453429, compound

Participants

Reaction Steps

To a cooled (0° C.) solution of tert-butyl 4-(4-cyclopropylpiperazin-1-yl)-4-(isonicotinamidomethyl)piperidine-1-carboxylate (0.541 mmol) in dioxane (1 ml/mmol) was added saturated dioxane-HCl solution (3.3 ml) and the reaction mixture was stirred at room temperature for 3 h. The solvent was evaporated and the residue was azeotroped with dioxane (3×). The crude product was used in the next step.

Provenance & Evidence