HRID460008

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13401996

3-Methoxyazetidine

C4H9NO

结构：CC(C)N1CCC(NC(=O)c2cc3cc(C(=O)O)ccc3n2Cc2cc(-c3ccc(Cl)s3)on2)CC1

HCID22394458

未命名化合物

结构：COc1cccc(Cn2c(C(=O)NC3CCN(C(C)C)CC3)cc3c(C(=O)O)cccc32)c1

HCID69507520

未命名化合物

PRODUCTS

生成物

结构：COc1cccc(Cn2c(C(=O)NC3CCN(C(C)C)CC3)cc3c(C(=O)N4CC(OC)C4)cccc32)c1

HCID67109136

未命名化合物

PROCEDURE

实验过程

The title compound was prepared analogously to example 1 with the difference that 3-Methoxy-azetidine and 2-(1-Isopropyl-piperidin-4-ylcarbamoyl)-1-(3-methoxy-benzyl)-1H-indole-4-carboxylic acid was used instead of Azetidin-3-ol and 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-2-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-indole-5-carboxylic acid. MS (ES+): m/e=519.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-29c82aa215c243df99440836af7afb77
来源数据集: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07196103B2
来源说明: uspto-grants-2007_03

反应 SMILES

[CH3:1][O:2][CH:3]1[CH2:6][NH:5][CH2:4]1.[CH:7]([N:10]1[CH2:15][CH2:14][CH:13]([NH:16][C:17]([C:19]2[N:20]([CH2:31][C:32]3[CH:37]=[CH:36][CH:35]=[C:34]([O:38][CH3:39])[CH:33]=3)[C:21]3[CH:22]=[CH:23][CH:24]=[C:25]([C:28](O)=[O:29])[C:26]=3[CH:27]=2)=[O:18])[CH2:12][CH2:11]1)([CH3:9])[CH3:8].ClC1SC(C2ON=C(CN3C4C(=CC(C(O)=O)=CC=4)C=C3C(=O)NC3CCN(C(C)C)CC3)C=2)=CC=1>>[CH:7]([N:10]1[CH2:15][CH2:14][CH:13]([NH:16][C:17]([C:19]2[N:20]([CH2:31][C:32]3[CH:37]=[CH:36][CH:35]=[C:34]([O:38][CH3:39])[CH:33]=3)[C:21]3[C:26]([CH:27]=2)=[C:25]([C:28]([N:5]2[CH2:6][CH:3]([O:2][CH3:1])[CH2:4]2)=[O:29])[CH:24]=[CH:23][CH:22]=3)=[O:18])[CH2:12][CH2:11]1)([CH3:9])[CH3:8]