反应详情

Triethylamine (2.5 equiv.) followed by acetyl chloride (1.2 equiv.) were added under cooled conditions to a solution of (1-benzyl-4-(4-(pyridin-4-yl)piperazin-1-yl)piperidin-4-yl)methanamine (4.67 mmol, 1 equiv.) in dichloromethane. The resulting solution was warmed to room temperature and stirred for 3 h. The mixture was diluted with dichloromethane and given water and brine washes respectively. The organic layer was dried over sodium sulfate, filtered and the solvent removed. The crude product was purified by column chromatography (silica). Yield: 52%

1. dry with materialThe organic layer was dried over sodium sulfate
2. filtrationfiltered
3. customthe solvent removed
4. customThe crude product was purified by column chromatography (silica)