HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Sulfide → 2-(4-Boc-aminophenyl)-thiazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Sulfide | HCID 402 | — |
| Reactant | Ethyl bromopyruvate | HCID 66144 | — |
| Reactant | Tert-butyl 3-amino-4-cyanobenzoate | HCID 18771825 | — |
| Reactant | 2-(p-Sulfamoylphenyl)thiazole-4-carboxylic acid | HCID 18772085 | — |
| Product | 2-(4-Boc-aminophenyl)-thiazole-4-carboxylic acid | HCID 69412598 | — |
Reaction Steps
In a manner similar to that described for the preparation of 2-(4-aminosulfonylphenyl)thiazole-4-carboxylic acid, 4-[(1,1-dimethylethoxy)carbonyl]-aminobenzonitrile was treated with H2S, ethyl bromopyruvate, and LIOH successively to give the title compound. MS m/z: 321 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07196104B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-6d9336aac5ce49a0b258eeea0dad86be |
| Source note | uspto-grants-2007_03 |