反应详情

To a stirred solution of ethyl 2-(2-methoxy-phenyl)thiazole-4-carboxylate (0.27 g, 1.03 mmol) in EtOH (10 mL) was added 1N NaOH (aq) (5 mL). The resulting mixture was heated to reflux for 2 h. The mixture was cooled to RT, acidified with 1N HCl (aq) and concentrated by rotary evaporation. The residue was extracted with CH2Cl2 (3×15 mL). The extracts were combined, dried over MgSO4, filtered and concentrated by rotary evaporation to afford the title compound as an off-white solid. EI-MS m/z 236 (M+H).

1. temperatureThe resulting mixture was heated
2. temperatureto reflux for 2 h
3. concentrationconcentrated by rotary evaporation
4. extractionThe residue was extracted with CH2Cl2 (3×15 mL)
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. concentrationconcentrated by rotary evaporation