反应详情

温度

40 °C

HCl (1.25 mL, 1.25 mmol) in MeOH (15 mL) was added to [6-(2,6-dimethyl-piperidin-1-ylmethyl)-pyridin-2-yl]-carbamic acid tert-butyl ester (200 mg, 0.63 mmol) followed by heating at 40° C. for 18 h. The resulting mixture was cooled to RT and basified to pH 9 with 2 N NaOH. The mixture was extracted with CHCl3 (3×20 mL). The combined organic layers was dried over MgSO4 and concentrated in vacuo to give a yellow oil. MS m/z: 220.2 (M+H). Calc'd. for C13H21N3-219.17.

1. extractionThe mixture was extracted with CHCl3 (3×20 mL)
2. dry with materialThe combined organic layers was dried over MgSO4
3. concentrationconcentrated in vacuo
4. customto give a yellow oil