反应详情

To a solution of 5-(4-ethoxycarbonyl-thiazol-2-yl)-indole-1-carboxylic acid tert-butyl ester (3.34 g, 9.0 mmol) and 125 mL of THF was added 1N NaOH (aq) (30.0 mL, 30.0 mmol). The solution was stirred for 24 h then concentrated in vacuo. The crude solid was redissolved in H2O and acidified with 5% KHSO4. The solid was filtered and dried in vacuo at 60° C. to give a pinkish-white solid. MS m/z: 345 (M+1). Calc'd for C17H16N2O4S-344.39.

1. concentrationthen concentrated in vacuo
2. dissolutionThe crude solid was redissolved in H2O
3. filtrationThe solid was filtered
4. customdried in vacuo at 60° C.
5. customto give a pinkish-white solid