Ammonium Hydroxide → HCID 18771962, compound

HRID 460227Notes

Reaction equation

HRID 460227 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH:8]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[CH3:9])[N:3]=1.[NH4+:16].[OH-]>>[N:10]1([CH:8]([C:4]2[N:3]=[C:2]([NH2:16])[CH:7]=[CH:6][CH:5]=2)[CH3:9])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 18771613HCID 18771613, compound

Product 1

HCID 18771962HCID 18771962, compound

Procedure

In a manner similar to that described in Preparation BW, 2-bromo-6-(1-piperidin-1-yl-ethyl)-pyridine (370 mg, 1.37 mmol) was heated with NH4OH (18 mL), IpOH (10 mL), and Cu (30 mg) in sealed tube to give a brown oil. MS m/z: 206.1 (M+H). Calc'd. for C12H19N3-205.16.

Workup

  1. customto give a brown oil

Sources & evidence

ORD record
ord-b1ac479e4c1f419d89b9e39eddc6cae7
Source dataset
uspto-grants-2007_03
Patent number
US07196104B2

Reaction notes

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