Hydrochloric Acid → HCID 18771795, compound

HRID 460228Notes

Reaction equation

HRID 460228 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[S:8][CH:9]=[C:10]([NH:12][C:13](=[O:33])[NH:14][C:15]3[N:20]=[C:19]([CH2:21][N:22]4[CH2:27][CH2:26][CH:25]([C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH2:24][CH2:23]4)[CH:18]=[CH:17][CH:16]=3)[N:11]=2)=[CH:3][CH:2]=1.[ClH:34]>CO>[ClH:34].[N:1]1[CH:2]=[CH:3][C:4]([C:7]2[S:8][CH:9]=[C:10]([NH:12][C:13](=[O:33])[NH:14][C:15]3[N:20]=[C:19]([CH2:21][N:22]4[CH2:27][CH2:26][CH:25]([C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH2:24][CH2:23]4)[CH:18]=[CH:17][CH:16]=3)[N:11]=2)=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18771796HCID 18771796, compound

Product 1

HCID 18771795HCID 18771795, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl 1-{6-[3-(2-pyridin-4-yl-thiazol-4-yl)-ureido]-pyridin-2-ylmethyl}-piperidine-4-carboxylate (50 mg, 0.05 mmol, Example 61) in MeOH (5 mL) was treated with HCl (0.12 mL, 0.06 mmol, 1M in Et2O) to afford the title salt as a yellow solid.

Sources & evidence

ORD record
ord-34af47acf3f04aef8a661b9455f3b1b9
Source dataset
uspto-grants-2007_03
Patent number
US07196104B2

Reaction notes

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