Hydrochloric Acid → HCID 18771707, compound

HRID 460232Notes

Reaction equation

[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[CH2:8][C:9]1[N:14]=[C:13]([NH:15][C:16]([NH:18][C:19]2[N:20]=[C:21]([C:24]3[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=3)[S:22][CH:23]=2)=[O:17])[CH:12]=[CH:11][CH:10]=1.[ClH:30]>>[ClH:30].[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[CH2:8][C:9]1[N:14]=[C:13]([NH:15][C:16]([NH:18][C:19]2[N:20]=[C:21]([C:24]3[CH:25]=[CH:26][N:27]=[CH:28][CH:29]=3)[S:22][CH:23]=2)=[O:17])[CH:12]=[CH:11][CH:10]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 18771660HCID 18771660, compound

Product 1

HCID 18771707HCID 18771707, compound

Procedure

1-[6-(2-Methylpiperidin-1-ylmethyl)pyridin-2-yl]-3-(2-pyridin-4-yl-thiazol-4-yl)urea (70 mg, 0.171 mmol, Example 66) was treated with HCl (0.19 mL, 0.188 mmol, 1M in Et2O) to afford the title salt as a yellow solid.

Sources & evidence

ORD record: ord-208c4b4a78154986a2ef71153c8e6e95
Source dataset: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07196104B2

Reaction notes

Loading…