Hydrochloric Acid → HCID 18771747, compound

HRID 460233Notes

Reaction equation

HRID 460233 reaction equation
[ClH:1].[N:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][CH:10]=[C:11]([NH:13][C:14](=[O:34])[NH:15][C:16]3[N:21]=[C:20]([CH2:22][N:23]4[CH2:28][CH2:27][CH2:26][CH:25]([C:29]([O:31][CH2:32][CH3:33])=[O:30])[CH2:24]4)[CH:19]=[CH:18][CH:17]=3)[N:12]=2)=[CH:4][CH:3]=1.CO>CCOCC>[ClH:1].[N:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:9][CH:10]=[C:11]([NH:13][C:14](=[O:34])[NH:15][C:16]3[N:21]=[C:20]([CH2:22][N:23]4[CH2:28][CH2:27][CH2:26][CH:25]([C:29]([O:31][CH2:32][CH3:33])=[O:30])[CH2:24]4)[CH:19]=[CH:18][CH:17]=3)[N:12]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 18771748HCID 18771748, compound

Product 1

HCID 18771747HCID 18771747, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

HCl (0.21 mL, 0.212 mmol, 1.0 M soln in Et2O) was added to ethyl 1-{6-[3-(2-pyridin-4-yl-thiazol-4-yl)ureido]-pyridin-2-ylmethyl}piperidine-3-carboxylate (90 mg, 0.193 mmol, Example 73) in a solution of MeOH (2 mL) to give a pale yellow solid.

Workup

  1. customto give a pale yellow solid

Sources & evidence

ORD record
ord-5b4eacfe26c14687bb4aa115054adcba
Source dataset
uspto-grants-2007_03
Patent number
US07196104B2

Reaction notes

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