Hydrochloric Acid → HCID 69410895, compound

HRID 460234Notes

Reaction equation

HRID 460234 reaction equation
[ClH:1].[N:2]1([CH2:9][C:10]2[N:15]=[C:14]([NH:16][C:17]([NH:19][C:20]3[N:21]=[C:22]([C:25]4[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=4)[S:23][CH:24]=3)=[O:18])[CH:13]=[CH:12][CH:11]=2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.CO>CCOCC>[ClH:1].[N:2]1([CH2:9][C:10]2[N:15]=[C:14]([NH:16][C:17]([NH:19][C:20]3[N:21]=[C:22]([C:25]4[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=4)[S:23][CH:24]=3)=[O:18])[CH:13]=[CH:12][CH:11]=2)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 59110543HCID 59110543, compound

Product 1

HCID 69410895HCID 69410895, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

HCl (0.29 mL, 0.28 mmol, 1.0 M soln in Et2O) was added to 1-(6-azepan-1-ylmethyl-pyridin-2-yl)-3-(2-pyridin-4-yl-thiazol-4-yl)urea (106 mg, 0.26 mmol, Example 71) in a solution of MeOH (4 mL) and the resulting mixture stirred 6 h. Concentration in vacuo gave a yellow solid.

Workup

  1. concentrationConcentration in vacuo
  2. customgave a yellow solid

Sources & evidence

ORD record
ord-0fdec9977db0413ea47885b12f8b0d6a
Source dataset
uspto-grants-2007_03
Patent number
US07196104B2

Reaction notes

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