Hydrochloric Acid → HCID 18771691, compound

HRID 460236Notes

Reaction equation

HRID 460236 reaction equation
[ClH:1].[Br:2][C:3]1[S:7][C:6]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)=[N:5][C:4]=1[NH:14][C:15]([NH:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][N:25]([CH2:28][CH3:29])[CH2:26][CH3:27])[N:19]=1)=[O:16].CO>CCOCC>[ClH:1].[Br:2][C:3]1[S:7][C:6]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)=[N:5][C:4]=1[NH:14][C:15]([NH:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][N:25]([CH2:28][CH3:29])[CH2:26][CH3:27])[N:19]=1)=[O:16]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 18771692HCID 18771692, compound

Product 1

HCID 18771691HCID 18771691, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

HCl (54 μL, 0.054 mmol, 1.0 M soln in Et2O) was added to 1-[5-bromo-2-(pyridin-4-yl)thiazol-4-yl)-3-(6-diethylaminomethyl-pyridin-2-yl)urea (25 mg, 0.054 mmol, Example 180) in a solution of MeOH (0.5 mL) to give a yellow solid.

Workup

  1. customto give a yellow solid

Sources & evidence

ORD record
ord-57a26b4a4cad40f1b7b31795546d8b71
Source dataset
uspto-grants-2007_03
Patent number
US07196104B2

Reaction notes

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