Hydrochloric Acid → HCID 18771720, compound

HRID 460238Notes

Reaction equation

HRID 460238 reaction equation
[ClH:1].[CH2:2]([N:4]([CH2:35][CH3:36])[C:5]([CH:7]1[CH2:12][CH2:11][CH2:10][N:9]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([NH:20][C:21]([NH:23][C:24]3[N:25]=[C:26]([C:29]4[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=4)[S:27][CH:28]=3)=[O:22])[N:15]=2)[CH2:8]1)=[O:6])[CH3:3].CO>CCOCC>[ClH:1].[CH2:35]([N:4]([CH2:2][CH3:3])[C:5]([CH:7]1[CH2:12][CH2:11][CH2:10][N:9]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([NH:20][C:21]([NH:23][C:24]3[N:25]=[C:26]([C:29]4[CH:30]=[CH:31][N:32]=[CH:33][CH:34]=4)[S:27][CH:28]=3)=[O:22])[N:15]=2)[CH2:8]1)=[O:6])[CH3:36]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 18771721HCID 18771721, compound

Product 1

HCID 18771720HCID 18771720, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

HCl (0.15 mL, 0.156 mmol, 1.0 M soln in Et2O) was added to N,N-diethyl 1-{6-[3-(2-pyridin-4-yl-thiazol-4-yl)-ureido]pyridin-2-ylmethyl}piperidine-3-carboxamide (70 mg, 0.142 mmol, Example 75) in a solution of MeOH (3 mL) to give a pale yellow solid.

Workup

  1. customto give a pale yellow solid

Sources & evidence

ORD record
ord-61bddc142cdb41a296882c9f8b6c9fb6
Source dataset
uspto-grants-2007_03
Patent number
US07196104B2

Reaction notes

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