5-Isobutyl-3,3-dimethyl-2,3-dihydrobenzofuran-7-boronic acid → 2,5-Difluoro-3-(5-isobutyl-3,3-dimethyl-2,3-dihydro-benzofuran-7-yl)-4-methoxy-benzaldehyde
Reaction equation
[CH2:1]([C:5]1[CH:6]=[C:7](B(O)O)[C:8]2[O:12][CH2:11][C:10]([CH3:14])([CH3:13])[C:9]=2[CH:15]=1)[CH:2]([CH3:4])[CH3:3].[F:19][C:20]1[C:27](I)=[C:26]([O:29][CH3:30])[C:25]([F:31])=[CH:24][C:21]=1[CH:22]=[O:23]>>[F:19][C:20]1[C:27]([C:7]2[C:8]3[O:12][CH2:11][C:10]([CH3:14])([CH3:13])[C:9]=3[CH:15]=[C:5]([CH2:1][CH:2]([CH3:4])[CH3:3])[CH:6]=2)=[C:26]([O:29][CH3:30])[C:25]([F:31])=[CH:24][C:21]=1[CH:22]=[O:23]Participants
3
Procedure
The intermediate 2,5-Difluoro-3-(5-isobutyl-3,3-dimethyl-2,3-dihydro-benzofuran-7-yl)-4-methoxy-benzaldehyde was prepared in a similar manner as in example 1 a using 5-isobutyl-3,3-dimethyl-2,3-dihydro-benzofuran-7-boronic acid (example 1b) and 2,5-difluoro-3-iodo-4-methoxy-benzaldehyde
Sources & evidence
- ORD record
- ord-09a46e86974743ae92552f0c5eacaf36
- Source dataset
- uspto-grants-2007_03
- Patent number
- US07196108B2
Reaction notes
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