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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 460295Generated: October 29, 2026

5-Isobutyl-3,3-dimethyl-2,3-dihydrobenzofuran-7-boronic acid → 2,5-Difluoro-3-(5-isobutyl-3,3-dimethyl-2,3-dihydro-benzofuran-7-yl)-4-methoxy-benzaldehyde

https://huagongshe.com/reaction/460295

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Isobutyl-3,3-dimethyl-2,3-dihydrobenzofuran-7-boronic acidHCID 11172680—
Reactant2,5-Difluoro-3-iodo-4-methoxy-benzaldehydeHCID 11312550—
Product2,5-Difluoro-3-(5-isobutyl-3,3-dimethyl-2,3-dihydro-benzofuran-7-yl)-4-methoxy-benzaldehydeHCID 11749156—

Reaction Steps

The intermediate 2,5-Difluoro-3-(5-isobutyl-3,3-dimethyl-2,3-dihydro-benzofuran-7-yl)-4-methoxy-benzaldehyde was prepared in a similar manner as in example 1 a using 5-isobutyl-3,3-dimethyl-2,3-dihydro-benzofuran-7-boronic acid (example 1b) and 2,5-difluoro-3-iodo-4-methoxy-benzaldehyde

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07196108B2
Source datasetuspto-grants-2007_03
ORD IDord-09a46e86974743ae92552f0c5eacaf36
Source noteuspto-grants-2007_03