HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 3-(tert-Butoxycarbonylamino)thiophene-2-carboxylic hydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Methyl 3-((tert-butoxycarbonyl)amino)thiophene-2-carboxylate | HCID 18925408 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(tert-Butoxycarbonylamino)thiophene-2-carboxylic hydrazide | HCID 18445944 | — |
Reaction Steps
0.4 g of hydrazine hydrate is added to a solution of 1.3 g of methyl 3-(tert-butoxycarbonylamino)thiophene-2-carboxylate in 10 ml of ethanol and the mixture is heated to reflux for 5 hours. After the volatile fractions had been removed under reduced pressure at 40° C., the remaining oil was purified by column chromatography (silica gel, eluent: methylene chloride:methanol=95:5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07196114B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-03da844bef1c40678bacab9c4d44810d |
| Source note | uspto-grants-2007_03 |