反应详情

0.4 g of hydrazine hydrate is added to a solution of 1.3 g of methyl 3-(tert-butoxycarbonylamino)thiophene-2-carboxylate in 10 ml of ethanol and the mixture is heated to reflux for 5 hours. After the volatile fractions had been removed under reduced pressure at 40° C., the remaining oil was purified by column chromatography (silica gel, eluent: methylene chloride:methanol=95:5).

1. temperaturethe mixture is heated
2. temperatureto reflux for 5 hours
3. customAfter the volatile fractions had been removed under reduced pressure at 40° C.
4. customthe remaining oil was purified by column chromatography (silica gel, eluent: methylene chloride:methanol=95:5)