反应详情

4 ml of a 20% toluenic phosgene solution are added dropwise to a solution of 240 mg of 3-(tert-butoxycarbonylamino)thiophene-2-carboxylic hydrazide in 5 ml of THF and the mixture is stirred at RT. After one hour, the mixture is admixed with 10 ml of water and, after brief digestion, extracted with ethyl acetate. After the ethyl acetate phase has been dried over sodium sulfate, the mixture is concentrated under reduced pressure and the remaining residue is used further without further purification.

1. extractionafter brief digestion, extracted with ethyl acetate
2. dry with materialAfter the ethyl acetate phase has been dried over sodium sulfate
3. concentrationthe mixture is concentrated under reduced pressure
4. customthe remaining residue is used further without further purification