Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | HCID 69143578 | HCID 69143578 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 18445938 | HCID 18445938 | — |
Reaction Steps
The solution of 300 mg of 1-(3-nitro-5-piperidine-1-sulfonylthiophen-2-yl)piperidine-4-carboxylic acid in 20 ml of ethyl acetate is admixed with 1.0 g of tin(II) chloride and stirred at 65° C. for 8 h. After cooling, it is stirred with 30 ml of water and filtered off with suction through Celite, and the ethyl acetate phase is removed, dried and concentrated under reduced pressure. This crude product is used further without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07196114B2 |
|---|
| Source dataset | uspto-grants-2007_03 |
|---|
| ORD ID | ord-505406fdb5464302864516f114c8f7a6 |
|---|
| Source note | uspto-grants-2007_03 |
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