Water → HCID 18445938, compound

HRID 460321Notes

Reaction equation

HRID 460321 reaction equation
[N+:1]([C:4]1[CH:8]=[C:7]([S:9]([N:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)(=[O:11])=[O:10])[S:6][C:5]=1[N:18]1[CH2:23][CH2:22][CH:21]([C:24]([OH:26])=[O:25])[CH2:20][CH2:19]1)([O-])=O.[Sn](Cl)Cl.O>C(OCC)(=O)C>[NH2:1][C:4]1[CH:8]=[C:7]([S:9]([N:12]2[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]2)(=[O:11])=[O:10])[S:6][C:5]=1[N:18]1[CH2:19][CH2:20][CH:21]([C:24]([OH:26])=[O:25])[CH2:22][CH2:23]1

Participants

5

Reactant 3

HCID 962WaterHCID 24479Stannous ChlorideHCID 69143578HCID 69143578, compound

Product 1

HCID 18445938HCID 18445938, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
65 °C

Procedure

The solution of 300 mg of 1-(3-nitro-5-piperidine-1-sulfonylthiophen-2-yl)piperidine-4-carboxylic acid in 20 ml of ethyl acetate is admixed with 1.0 g of tin(II) chloride and stirred at 65° C. for 8 h. After cooling, it is stirred with 30 ml of water and filtered off with suction through Celite, and the ethyl acetate phase is removed, dried and concentrated under reduced pressure. This crude product is used further without further purification.

Workup

  1. temperatureAfter cooling
  2. filtrationfiltered off with suction through Celite
  3. customthe ethyl acetate phase is removed
  4. customdried
  5. concentrationconcentrated under reduced pressure
  6. customThis crude product is used further without further purification

Sources & evidence

ORD record
ord-505406fdb5464302864516f114c8f7a6
Source dataset
uspto-grants-2007_03
Patent number
US07196114B2

Reaction notes

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