2-Chloro-4,5-difluorobenzoyl Isocyanate → HCID 18445937, compound

HRID 460322Notes

Reaction equation

HRID 460322 reaction equation
[NH2:1][C:2]1[CH:6]=[C:5]([S:7]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)(=[O:9])=[O:8])[S:4][C:3]=1[N:16]1[CH2:21][CH2:20][CH:19]([C:22]([OH:24])=[O:23])[CH2:18][CH2:17]1.[Cl:25][C:26]1[CH:36]=[C:35]([F:37])[C:34]([F:38])=[CH:33][C:27]=1[C:28]([N:30]=[C:31]=[O:32])=[O:29]>C(#N)C>[Cl:25][C:26]1[CH:36]=[C:35]([F:37])[C:34]([F:38])=[CH:33][C:27]=1[C:28]([NH:30][C:31](=[O:32])[NH:1][C:2]1[CH:6]=[C:5]([S:7]([N:10]2[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]2)(=[O:9])=[O:8])[S:4][C:3]=1[N:16]1[CH2:17][CH2:18][CH:19]([C:22]([OH:24])=[O:23])[CH2:20][CH2:21]1)=[O:29]

Participants

4

Reactant 2

HCID 115575832-Chloro-4,5-difluorobenzoyl IsocyanateHCID 18445938HCID 18445938, compound

Product 1

HCID 18445937HCID 18445937, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

1-[3-Amino-5-(piperidine-1-sulfonyl)thiophen-2-yl]piperidine-4-carboxylic acid (0.2 g of crude product) is dissolved in 2 ml of acetonitrile and admixed with the equimolar solution of 2-chloro-4,5-difluorobenzoyl isocyanate in acetonitrile, and the mixture is stirred at RT. After 3 hours, the solid is filtered off with suction and dried under reduced pressure.

Workup

  1. filtrationthe solid is filtered off with suction
  2. customdried under reduced pressure

Sources & evidence

ORD record
ord-2dd4f6921ff047e79a97ee0d5f8291ef
Source dataset
uspto-grants-2007_03
Patent number
US07196114B2

Reaction notes

Loading…