反应详情

To a solution of 4-azido-3-hydroxy-azepane-1-carboxylic acid benzyl ester (3.3 g, 11.37 mmol) in methanol (50 mL) was added triethylamine (5 mL) and 1,3-propanedithiol (3.42 mL, 35 mmol). The mixture was stirred at ambient temperature until TLC analysis showed complete consumption of the starting material. A white precipitate was removed by filtration and the filtrate was evaporated to dryness. The residue was triturated with a 1:1 hexane/diethyl ether mixture to remove excess dithiol and dried under vacuum to yield 4-amino-3-hydroxy-azepane-1-carboxylic acid benzyl ester.

1. customconsumption of the starting material
2. customA white precipitate was removed by filtration
3. customthe filtrate was evaporated to dryness
4. customThe residue was triturated with a 1:1 hexane/diethyl ether mixture
5. customto remove excess dithiol
6. customdried under vacuum