反应详情

A mixture of methyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate (1.5 g), 2-(aminomethyl)piperidine (0.62 g) in toluene (3 ml) was stirred at reflux for 10 hours. After cooling to room temperature, water (10 ml) was added and two layers solution were separated. The aqueous layer was extracted with toluene (2×10 ml) and the combined organic layers were washed with water (3×10 ml). The organic layer was concentrated under reduced pressure to give Flecainide free base as a white solid (1.63 g, 85%).

1. temperatureat reflux for 10 hours
2. customtwo layers solution were separated
3. extractionThe aqueous layer was extracted with toluene (2×10 ml)
4. washthe combined organic layers were washed with water (3×10 ml)
5. concentrationThe organic layer was concentrated under reduced pressure