HRID460435

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID78373

Methanamine, 1,1-dimethoxy-N,N-dimethyl-

C5H13NO2

HCID2807782

Ethyl 3-[4-amino-2-(methylsulfanyl)-1,3-thiazol-5-yl]-3-oxopropanoate

C9H12N2O3S2

PRODUCTS

生成物

$结构：CCOC(=O)/C(=C\N(C)C)C(=O)c1sc(SC)nc1/N=C/N(C)C$

HCID13297627

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

A mixture of EXAMPLE 1A (8.8 g) and N,N-dimethyl-formamide dimethyl acetal (15.1 g) in toluene (170 mL) at 110° C. was stirred for 3 hours, concentrated to half volume, cooled, and filtered. 1H NMR (300 MHz, CDCl3) δ 8.40 (s, 1H), 7.42 (s, 1H), 3.99 (q, 2H), 3.05 (d, 6H), 2.92 (b, 6H), 2.65 (s, 3H), 1.04 (t, 3H).

WORKUP

后处理

concentrationconcentrated to half volume
temperaturecooled
filtrationfiltered