反应详情

6-Methoxy-2-naphthol (22.1 g, 127.0 mmol) was dissolved in acetone (200 ml). Potassium carbonate (70.2 g, 508.0 mmol) and allyl bromide (16.5 ml, 191.0 mmol) were added to the resulting solution followed by stirring for 2 days at room temperature. After the reaction mixture was filtered, the organic solvent was distilled off under reduced pressure. Water was added to the residue, which was then extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride and dried over anhydrous sodium sulfate. The organic solvent was distilled off again to give 6-methoxy-2-(2-propenyloxy)naphthalene (24.9 g, Yield 91%) as a crude product.

1. filtrationAfter the reaction mixture was filtered
2. distillationthe organic solvent was distilled off under reduced pressure
3. additionWater was added to the residue, which
4. extractionwas then extracted with ethyl acetate
5. washThe organic layer was washed with saturated aqueous sodium chloride
6. dry with materialdried over anhydrous sodium sulfate
7. distillationThe organic solvent was distilled off again