Ammonia → HCID 136386015, compound

HRID 460645Notes

Reaction equation

HRID 460645 reaction equation
[CH3:1][O:2][C:3]1[CH:16]=[CH:15][CH:14]=[CH:13][C:4]=1[CH:5]=[C:6]1[C:10](=O)[O:9][C:8]([CH3:12])=[N:7]1.[NH3:17].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[CH3:1][O:2][C:3]1[CH:16]=[CH:15][CH:14]=[CH:13][C:4]=1[CH:5]=[C:6]1[N:7]=[C:8]([CH3:12])[NH:17][C:10]1=[O:9]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 11430Potassium CarbonateHCID 361416HCID 361416, compound

Product 1

HCID 136386015HCID 136386015, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

4-(2′-Methoxybenzylidene)-2-methyl-4H-oxazol-5-one (2.4 g) was dissolved in ethanol (50 ml) and aqueous ammonia (20 ml) and potassium carbonate (3 g) were added. The mixture was heated at 80° C. for 10 hr. After cooling, the solvent was evaporated under reduced pressure and water was added to the residue. The mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The precipitated yellow crystals were collected by filtration to give the title compound (2 g).

Workup

  1. temperatureAfter cooling
  2. customthe solvent was evaporated under reduced pressure and water
  3. additionwas added to the residue
  4. extractionThe mixture was extracted with ethyl acetate
  5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  6. concentrationconcentrated under reduced pressure
  7. filtrationThe precipitated yellow crystals were collected by filtration

Sources & evidence

ORD record
ord-405aca270de946a5a9f15a223cf586a5
Source dataset
uspto-grants-2007_03
Patent number
US07196199B2

Reaction notes

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