HRID460737

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID887

Methanol

CH4O

HCID962

Water

H2O

2 次

结构：CCCCCCCCCCCCCC(=O)Nc1ccc(Cl)c(NC2=NN(c3c(Cl)cc(Cl)cc3Cl)C(=O)C2)c1

HCID178443172

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCC(=O)Nc1ccc(Cl)c(Nc2cc(=O)n(-c3c(Cl)cc(Cl)cc3Cl)n2C(=O)Oc2ccccc2)c1

HCID22762275

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

A solution of 30.7 g (0.05 mole) of 1-(2,4,6-trichlorophenyl)-3-(2-chloro-5-myristoylamino-anilino)-2-pyrazolin-5-one and 15.6 g (0.1 mole) of phenyl chloroformiate in 100 ml of acetonitrile are refluxed for 4 h. The solution is poured out in water and the separated oil is stirred first with water and next with methanol. The precipitate is recrystallized from ethanol.

WORKUP

后处理

customThe precipitate is recrystallized from ethanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-be249b6a1114491a91def0ad79430d48
来源数据集: uspto-grants-1977_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04061498
来源说明: uspto-grants-1977_12

反应 SMILES

[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[N:10]1[C:14](=[O:15])[CH2:13][C:12]([NH:16][C:17]2[CH:22]=[C:21]([NH:23][C:24](=[O:38])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH:20]=[CH:19][C:18]=2[Cl:39])=[N:11]1.[CH3:40][OH:41].[OH2:42]>C(#N)C>[Cl:9][C:4]1[CH:5]=[C:6]([Cl:8])[CH:7]=[C:2]([Cl:1])[C:3]=1[N:10]1[C:14](=[O:15])[CH:13]=[C:12]([NH:16][C:17]2[CH:22]=[C:21]([NH:23][C:24](=[O:38])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH:20]=[CH:19][C:18]=2[Cl:39])[N:11]1[C:40]([O:42][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:41]