Sulfuryl chloride → HCID 21394040, compound

HRID 460738Notes

Reaction equation

HRID 460738 reaction equation
S(Cl)([Cl:4])(=O)=O.[Cl:6][C:7]1[CH:12]=[C:11]([Cl:13])[CH:10]=[C:9]([Cl:14])[C:8]=1[N:15]1[C:19](=[O:20])[CH:18]=[C:17]([NH:21][C:22]2[CH:27]=[C:26]([NH:28][C:29](=[O:43])[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])[CH:25]=[CH:24][C:23]=2[Cl:44])[N:16]1[C:45]([O:47][CH2:48][CH3:49])=[O:46]>ClCCl>[Cl:6][C:7]1[CH:12]=[C:11]([Cl:13])[CH:10]=[C:9]([Cl:14])[C:8]=1[N:15]1[C:19](=[O:20])[C:18]([Cl:4])=[C:17]([NH:21][C:22]2[CH:27]=[C:26]([NH:28][C:29](=[O:43])[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])[CH:25]=[CH:24][C:23]=2[Cl:44])[N:16]1[C:45]([O:47][CH2:48][CH3:49])=[O:46]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 22762272HCID 22762272, compound2×

Product 1

HCID 21394040HCID 21394040, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4.45 ml (0.055 mole) of sulfuryl chloride are added dropwise in 15 min at -50° C to a cooled solution of 34.4 g (0.05 mole) of 1-(2,4,6-trichlorophenyl)-2-ethoxycarbonyl-3-(2-chloro-5-myristoylamino-anilino)-3-pyrazolin-5-one (compound 19) in 100 ml dichloromethane.

Sources & evidence

ORD record
ord-17dc7f76fe9d46519216082e0729e5e4
Source dataset
uspto-grants-1977_12
Patent number
US04061498

Reaction notes

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