Methacryloyl chloride → HCID 21394033, compound

Participants

Reaction Steps

123.5 g (0.5 mole) of 1-phenyl-2-ethoxycarbonyl-3-amino-3-pyrazolin-5-one (compound 2) are dissolved at room temperature in a solution of 133.5 g (1 mole) of anhydrous aluminium chloride and 15 ml of nitrobenzene in 500 ml of acetonitrile. The resulting solution is mixed with 57.5 g (0.55 mole) of methacryloyl chloride and is then refluxed for 3 h. The reaction mixture is poured out in 1 l of water and the precipitate formed is separated. The product is recrystallized from benzene/hexane (1:1).

Provenance & Evidence