Phenyl Isothiocyanate → HCID 12608502, compound

HRID 460783Notes

Reaction equation

HRID 460783 reaction equation
[CH3:1][NH:2][CH:3]1[CH2:8][CH2:7][N:6]([CH2:9][CH2:10][C:11]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[NH:13][CH:12]=2)[CH2:5][CH2:4]1.[C:20]1([N:26]=[C:27]=[S:28])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C1C=CC=CC=1>[NH:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]([CH2:10][CH2:9][N:6]2[CH2:5][CH2:4][CH:3]([N:2]([CH3:1])[C:27]([NH:26][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[S:28])[CH2:8][CH2:7]2)=[CH:12]1

Participants

4

Reactant 2

HCID 7673Phenyl IsothiocyanateHCID 12608469HCID 12608469, compound

Product 1

HCID 12608502HCID 12608502, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

3-[2-(4-Methylaminopiperidyl)ethyl]indole (1.28g, 0.005 mole) was stirred in dry benzene (75 ml) and treated with phenyl isothiocyanate (0.74g, 0.0055 mole). Stirring was continued for 24 hr. and the mixture evaporated to give the title compound, which was converted to the hydrochloride by addition of hydrogen chloride in ethanol and precipitation with ether. Yield, 0.95g, m.p. 193.7°.

Workup

  1. customand the mixture evaporated

Sources & evidence

ORD record
ord-9f20d5bb67464953b0d4f5c11f7945d4
Source dataset
uspto-grants-1977_12
Patent number
US04061641

Reaction notes

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