N,N'-Dicyclopropylthiourea → 4-(2,4-Dichloro-5-sulfamoylphenyl)-3-cyclopropyl-2-cyclopropylimino-1,3-thiazolidine-4-ol-hydrobromide

HRID 460822Notes

Reaction equation

HRID 460822 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])[C:8]([Cl:15])=[CH:7][C:6]=1[Cl:16])=[O:4].[CH:17]1([NH:20][C:21]([NH:23][CH:24]2[CH2:26][CH2:25]2)=[S:22])[CH2:19][CH2:18]1>>[BrH:1].[Cl:16][C:6]1[CH:7]=[C:8]([Cl:15])[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])=[CH:10][C:5]=1[C:3]1([OH:4])[CH2:2][S:22][C:21](=[N:20][CH:17]2[CH2:19][CH2:18]2)[N:23]1[CH:24]1[CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 17750075N,N'-DicyclopropylthioureaHCID 227564292-Bromo-2',4'-dichloro-5'-sulfamoylacetophenone

Product 1

HCID 213947924-(2,4-Dichloro-5-sulfamoylphenyl)-3-cyclopropyl-2-cyclopropylimino-1,3-thiazolidine-4-ol-hydrobromide

Procedure

was obtained in a manner analogous to that described in Example 10 from 3.5 g of 2-bromo-2',4'-dichloro-5'-sulfamoylacetophenone and 1.6 g of 1,3-dicyclopropyl-thiourea. M.p. 226° C (decomposition).

Workup

  1. customwas obtained in a manner analogous to

Sources & evidence

ORD record
ord-b60a71bba19d469eac652455f96bab82
Source dataset
uspto-grants-1977_12
Patent number
US04061647

Reaction notes

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