N-methyl-N'-phenethylthiourea → 4-(2,4-Dichloro-5-sulfamoylphenyl)-3-methyl-2-(2-phenylethylimino)-1,3-thiazolidine-4-ol-hydrobromide

HRID 460825Notes

Reaction equation

HRID 460825 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])[C:8]([Cl:15])=[CH:7][C:6]=1[Cl:16])=[O:4].[CH3:17][NH:18][C:19]([NH:21][CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[S:20]>>[BrH:1].[Cl:16][C:6]1[CH:7]=[C:8]([Cl:15])[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])=[CH:10][C:5]=1[C:3]1([OH:4])[CH2:2][S:20][C:19](=[N:21][CH2:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[N:18]1[CH3:17]

Participants

3

Reactant 2

HCID 2725299N-methyl-N'-phenethylthioureaHCID 227564292-Bromo-2',4'-dichloro-5'-sulfamoylacetophenone

Product 1

HCID 213947814-(2,4-Dichloro-5-sulfamoylphenyl)-3-methyl-2-(2-phenylethylimino)-1,3-thiazolidine-4-ol-hydrobromide

Procedure

was obtained in a manner analogous to the method described in Example 10 from 3.5 g of 2-bromo-2',4'-dichloro-5'-sulfamoylacetophenone and 2 g of 1-methyl-3-(2-phenylethyl)-thiourea. M.p. 164°-165° C (decomposition)

Workup

  1. customwas obtained in a manner analogous to the method

Sources & evidence

ORD record
ord-13cac9613dff408e8a7bec1e1731c764
Source dataset
uspto-grants-1977_12
Patent number
US04061647

Reaction notes

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