Benzyl Alcohol → HCID 22759231, compound

HRID 460859Notes

Reaction equation

HRID 460859 reaction equation
[H-].[Na+].[CH2:3]([OH:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[C:11]([CH:14]([CH2:26][CH2:27][CH2:28][CH:29]1[O:31][CH2:30]1)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])(=[O:13])[CH3:12]>O>[C:11]([CH:14]([CH2:26][CH2:27][CH2:28][CH:29]([OH:31])[CH2:30][O:10][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([O:23][CH2:24][C:25]1[CH:8]=[CH:9][CH:4]=[CH:5][CH:6]=1)=[O:22])(=[O:13])[CH3:12]

Participants

5

Reactant 3

HCID 244Benzyl AlcoholHCID 24758Sodium hydrideHCID 22759269HCID 22759269, compound

Product 1

HCID 22759231HCID 22759231, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Sodium hydride (0.04 mole) is added in portions with stirring to benzyl alcohol (25 ml.). To the resulting solution, ethyl 8-acetyl-12,13-epoxytridecanoate (0.02 mole) is added and the mixture allowed to stand 18 hours at 55°-60°. The reaction mixture is then cooled and treated with water. The organic layer is separated and dried over magnesium sulfate. Excess benzyl alcohol is removed by distillation in vacuo by means of the rotary evaporator at oil pump pressure. The residue consists mainly of the title compound and is used in the next step without purification.

Workup

  1. temperatureThe reaction mixture is then cooled
  2. customThe organic layer is separated
  3. dry with materialdried over magnesium sulfate
  4. customExcess benzyl alcohol is removed by distillation in vacuo by means of the rotary evaporator at oil pump pressure
  5. customis used in the next step without purification

Sources & evidence

ORD record
ord-dc7725c771974fbe941a4793432df51b
Source dataset
uspto-grants-1977_12
Patent number
US04061643

Reaction notes

Loading…