Ethanol → HCID 20367246, compound

HRID 460895Notes

Reaction equation

HRID 460895 reaction equation
C[N:2]([CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[CH:6]=1)[NH2:3].C(OC(=O)C=[C:17]([NH2:21])OCC)C.[C:23]1(C)C=CC(S(O)(=O)=O)=CC=1.[CH2:34]([OH:36])[CH3:35]>>[NH2:21][C:17]1[NH:3][N:2]([CH2:4][C:5]2[CH:10]=[CH:9][C:8]([CH3:23])=[C:7]([Cl:11])[CH:6]=2)[C:34](=[O:36])[CH:35]=1

Participants

5

Reactant 4

HCID 702EthanolHCID 6101p-Toluenesulfonic acidHCID 278451beta-Aminobeta-ethoxyacrylic acid ethyl esterHCID 21394869HCID 21394869, compound

Product 1

HCID 20367246HCID 20367246, compound

Procedure

50 g of 4 methyl-3-chlorobenzylhydrazine were added dropwise, under nitrogen, to a solution of 46.7 g of β-amino-β-ethoxyacrylic acid ethyl ester and 1.5 g of p-toluene-sulphonic acid in 200 ml of ethanol. After stirring for a further two hours, the compound identified above precipitated. It was filtered off and recrystallised from ethanol. Melting point: 130°-131°, 35 g (50%).

Workup

  1. customabove precipitated
  2. filtrationIt was filtered off
  3. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-bedddbbe22c5495f9ced7605692625db
Source dataset
uspto-grants-1977_12
Patent number
US04061653

Reaction notes

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