Acetic Acid → HCID 20285748, compound

HRID 460964Notes

Reaction equation

HRID 460964 reaction equation
[CH3:1][C:2]1[S:3][C:4]([Cl:8])=[C:5](C)[CH:6]=1.C=O.[ClH:11].[C:12](O)(=O)[CH3:13]>>[CH3:1][C:2]1[S:3][C:4]([Cl:8])=[C:12]([CH3:13])[C:6]=1[CH2:5][Cl:11]

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 12875260HCID 12875260, compound

Product 1

HCID 20285748HCID 20285748, compound

Procedure

3.04 G. of 2,4-dimethyl-5-chloro-thiophene are dissolved in 60 ml. of acetic acid and 2.1 g. of formalin and 32 ml. of concentrated hydrochloric acid are added. The mixture is stirred at room temperature for 2 hours, then poured into ice water and extracted with hexane. The organic solution is washed with 5% sodium bicarbonate solution, dried, filtered and evaporated to yield 2,4-dimethyl-3-chloromethyl-5-chloro-thiophene.

Workup

  1. extractionextracted with hexane
  2. washThe organic solution is washed with 5% sodium bicarbonate solution
  3. customdried
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-1aef69de4d87467abc9c9e122df9b7a3
Source dataset
uspto-grants-1977_12
Patent number
US04061656

Reaction notes

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