反应详情

Sodium (0.432 g., 0.0188 mole) was added to β-diethylaminoethanol (2.23 g., 0.0190 mole) in dry toluene (80 ml) and the mixture was refluxed to give a complete solution. 4-Benzamidopiperidine-1-carbonyl chloride (4.2 g., 0.01575 mole) in suspension in dry toluene (150 ml.) was added in portions and the mixture refluxed for 21/2 hours. Water was added to the mixture, the toluene layer was collected, dried and evaporated to give the title compound (3.27 g. 37%), melting point 78°-82° C.

1. temperaturethe mixture was refluxed
2. customto give a complete solution
3. temperaturethe mixture refluxed for 21/2 hours
4. customthe toluene layer was collected
5. customdried
6. customevaporated