Formaldehyde → HCID 23455198, compound

HRID 461011Notes

Reaction equation

HRID 461011 reaction equation
[N:1]1([C:12](=[O:13])[C:11]2[NH:10][CH:9]=[N:8][C:7]=2[N:5]([CH3:6])[C:3]1=[O:4])[CH3:2].[ClH:14].[N:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[CH2:21]=O>>[Cl-:14].[N:15]1([CH2:21][N:10]2[C:11]3[C:12](=[O:13])[N:1]([CH3:2])[C:3](=[O:4])[N:5]([CH3:6])[C:7]=3[N:8]=[CH:9]2)[CH:20]=[CH:19][CH:18]=[CH:17][CH2:16]1

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 2153TheophyllineHCID 10176127Pyridinium chloride

Product 1

HCID 23455198HCID 23455198, compoundYield 78.2%

Procedure

A suspension of 3.60 g (0.02 mole) of theophylline, 2.30 g (0.02 mole) of pyridine hydrochloride and 0.7 g (0.023 mole) of paraformaldehyde was heated at 80° for 24 hr. Upon cooling, crystals immediately formed in the solution. The crystals were filtered and dried in vacuo to give 4.83 g (28% yield) of the desired compound as its hydrate.

Workup

  1. temperaturewas heated at 80° for 24 hr
  2. temperatureUpon cooling
  3. customcrystals immediately formed in the solution
  4. filtrationThe crystals were filtered
  5. customdried in vacuo

Sources & evidence

ORD record
ord-09a9bf2ad8f542c58e4a6927355828e6
Source dataset
uspto-grants-1977_12
Patent number
US04061753

Reaction notes

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