2H-Azepine, 3,4,5,6-tetrahydro-7-methoxy- → HCID 178478542, compound

HRID 461021Notes

Reaction equation

HRID 461021 reaction equation
Cl.[Cl:2][C:3]1[CH:11]=[CH:10][C:6]([CH2:7][CH2:8][NH2:9])=[CH:5][CH:4]=1.CO[C:14]1[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][N:20]=1>>[ClH:2].[Cl:2][C:3]1[CH:11]=[CH:10][C:6]([CH2:7][CH2:8][N:9]=[C:14]2[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 756572H-Azepine, 3,4,5,6-tetrahydro-7-methoxy-HCID 122515192-(4-Chlorophenyl)ethan-1-amine--hydrogen chloride (1/1)

Product 1

HCID 178478542HCID 178478542, compound

Procedure

A slurry of 15.9 g (0.08 mole) of p-chlorophenethylamine hydrochloride in 25 ml of O-methylcaprolactim is allowed to stand at room temperature 3 days with occasional stirring with a glass rod. The mixture is then cooled and the resulting solid is collected, washed with ether and recrystallized from methanol-acetone to give 2-(p-chlorophenylethylimino)hexahydroazapine hydrochloride.

Workup

  1. temperatureThe mixture is then cooled
  2. customthe resulting solid is collected
  3. washwashed with ether
  4. customrecrystallized from methanol-acetone

Sources & evidence

ORD record
ord-5b278b0be4584379833361726e6a865c
Source dataset
uspto-grants-1977_12
Patent number
US04061746

Reaction notes

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