rac-(1R,2R)-2-phenylcyclopentan-1-amine hydrochloride → N-[(1R,2S)-2-cyclohexylcyclopentyl]azepan-2-imine;hydrochloride

Participants

Reaction Steps

By the procedure described in Example 25(A) only substituting for cis-2-phenylcyclopentylamine hydrochloride an appropriate amount of trans-2-phenylcyclopentylamine hydrochloride, M.P. 142°-143° C, the hydrochloride salt of trans-2-cyclohexylcyclopentylamine is obtained, M.P. 199°-200° C. Following the procedure of Example 23 only substituting for cis-2-phenylcyclopentylamine hydrochloride and appropriate amount of trans-2-cyclohexylcyclopentylamine hydrochloride and employing a reaction time of 38 days, the desired product is obtained, M.P. 208°-210° C.

Provenance & Evidence