N-Methyl-N'-[(pyridin-2-yl)methyl]thiourea → HCID 22760667, compound

HRID 461144Notes

Reaction equation

HRID 461144 reaction equation
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)=[O:4].[CH3:16][NH:17][C:18]([NH:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=1)=[S:19]>>[ClH:1].[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2([OH:4])[CH2:2][S:19][C:18](=[N:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=3)[N:17]2[CH3:16])=[CH:6][C:7]=1[S:12](=[O:15])(=[O:14])[NH2:13]

Participants

3

Reactant 2

HCID 12629156N-Methyl-N'-[(pyridin-2-yl)methyl]thioureaHCID 213167492,4'-Dichloro-3'-sulfamoylacetophenone

Product 1

HCID 22760667HCID 22760667, compound

Procedure

5.2 g of 2,4'-dichloro-3'-sulfamoylacetophenone and 3.5 g of 1-methyl-3-(2-pyridylmethyl)-thiourea were reacted as prescribed in Example 12 and the end product was precipitated with 400 ml of ethyl acetate while stirring. Colorless crystals, melting point 152° C (decomposition) γC=N 1620 cm-1.

Workup

  1. customthe end product was precipitated with 400 ml of ethyl acetate

Sources & evidence

ORD record
ord-613d4b1851a34368981151a893623baf
Source dataset
uspto-grants-1977_12
Patent number
US04061761

Reaction notes

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