反应详情

温度

60 °C

12.6 g of 4'-chloro-3'-chlorosulfonylacetophenone were introduced, while stirring, in a mixture of 5.6 g of aniline, 7.5 g of triethyl amine and 100 ml of dioxane. The mixture was allowed to dwell over night at 20° C, it was heated to 60° C during 30 minutes while stirring and the separated triethylamine-hydrochloride was separated. The filtrate was concentrated under reduced pressure and the residue was crystallized under water. Colorless crystals (from isopropanol/active charcoal, melting point: 142° C.

1. waitto dwell over night at 20° C
2. customthe separated triethylamine-hydrochloride was separated
3. concentrationThe filtrate was concentrated under reduced pressure
4. customthe residue was crystallized under water