Benzhydrylamine → 4-(3-Benzhydrylsulfamoyl-4-chlorophenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol

HRID 461183Notes

Reaction equation

HRID 461183 reaction equation
Br.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([OH:17])[CH2:13][S:12][C:11](=[N:14][CH3:15])[N:10]2[CH3:16])=[CH:5][C:4]=1[S:18](Cl)(=[O:20])=[O:19].[CH:22]([NH2:35])([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>C(N(CC)CC)C>[CH:22]([NH:35][S:18]([C:4]1[CH:5]=[C:6]([C:9]2([OH:17])[CH2:13][S:12][C:11](=[N:14][CH3:15])[N:10]2[CH3:16])[CH:7]=[CH:8][C:3]=1[Cl:2])(=[O:20])=[O:19])([C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 7036BenzhydrylamineHCID 227604894-Chloro-3-chlorosulfonylphenyl-3-methyl-2-methylimino-1,3-thiazolidine-4-ol-hydrobromide

Product 1

HCID 541302204-(3-Benzhydrylsulfamoyl-4-chlorophenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

6.5 g of 4-(4-chloro-3-chlorosulfonylphenyl)-3-methyl-2-methylimino-1,3-thiazolidine-4-ol-hydrobromide were reacted as prescribed in Example 76 with 2.7 g of benzhydrylamine and 4 g of triethyl amine and worked up. Colorless solid body, decomposition beginning at 103° C, γ C=N 1620 cm-1.

Workup

  1. customat 103° C

Sources & evidence

ORD record
ord-136bb6765b4b4d5384ca8df45c804e7d
Source dataset
uspto-grants-1977_12
Patent number
US04061761

Reaction notes

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